RNA Details
Disease Name
Hypertension Pulmonary
Tissue
lung
RNA Symbol
let-7b
RNA ID
RNA Type
miRNA
Alteration Pattern
down regulation
Species
homo sapiens
Detection Methods
qRT-PCR; ELISA etc.
Target
ET-1; TGFBR1
Pathway
NA
PubMed ID
Title
Differentially Expressed Plasma MicroRNAs and the Potential Regulatory Function of Let-7b in Chronic Thromboembolic Pulmonary Hypertension
Year
2014
Function
"35 MicroRNAs were differentially expressed in CTEPH patients, among which, a signature of 17 microRNAs was shown to be related to the disease pathogenesis by in silico analysis. Let-7b, one of the down-regulated anti-oncogenic microRNAs in the signature, was validated to decrease in CTEPH patients. ET-1 and TGFBR1 were direct targets of let-7b. Altering let-7b level influenced ET-1 and TGFBR1 expression in pulmonary arterial endothelial cells (PAECs) as well as the migration of PAECs and pulmonary arterial smooth muscle cells (PASMCs). CTEPH patients had aberrant microRNA signature which might provide some clue for pathogenesis study and biomarker screening. Reduced let-7b might be involved in the pathogenesis of CTEPH by affecting ET-1 expression and the function of PAECs and PASMCs."